Tumor Necrosis Factor α-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1): POSSIBLE MECHANISM FOR SUPPRESSION OF INSULIN-STIMULATED …
H Kanety, R Feinstein, MZ Papa, R Hemi… - Journal of Biological …, 1995 - ASBMB
Tumor necrosis factor-α (TNF) has been suggested to be the mediator of insulin resistance
in infection, tumor cachexia, and obesity. We have previously shown that TNF diminishes
insulin-induced tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1). The current
work examines potential mechanisms that mediate this event. TNF effect on IRS-1 in Fao
hepatoma cells was not associated with a significant reduction in insulin receptor tyrosine
kinase activity as measured in vitro but impaired the association of IRS-1 with …
in infection, tumor cachexia, and obesity. We have previously shown that TNF diminishes
insulin-induced tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1). The current
work examines potential mechanisms that mediate this event. TNF effect on IRS-1 in Fao
hepatoma cells was not associated with a significant reduction in insulin receptor tyrosine
kinase activity as measured in vitro but impaired the association of IRS-1 with …
