Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice
RL Coffman, BWP Seymour, S Hudak, J Jackson… - Science, 1989 - science.org
RL Coffman, BWP Seymour, S Hudak, J Jackson, D Rennick
Science, 1989•science.orgWhen rodents are infected with the nematode Nippostrongylus brasiliensis, large numbers
of eosinophils appear in their blood and lungs and their serum immunoglobulin E (IgE) is
increased. Injection of a monoclonal antibody to interleukin-5 completely suppressed the
blood eosinophilia and the infiltration of eosinophils in the lungs of parasitized mice but had
no effect on serum IgE. In contrast, an antibody to interleukin-4 inhibited parasite-induced
IgE but not the eosinophilia. These results show that interleukin-5 is important in eosinophil …
of eosinophils appear in their blood and lungs and their serum immunoglobulin E (IgE) is
increased. Injection of a monoclonal antibody to interleukin-5 completely suppressed the
blood eosinophilia and the infiltration of eosinophils in the lungs of parasitized mice but had
no effect on serum IgE. In contrast, an antibody to interleukin-4 inhibited parasite-induced
IgE but not the eosinophilia. These results show that interleukin-5 is important in eosinophil …
When rodents are infected with the nematode Nippostrongylus brasiliensis, large numbers of eosinophils appear in their blood and lungs and their serum immunoglobulin E (IgE) is increased. Injection of a monoclonal antibody to interleukin-5 completely suppressed the blood eosinophilia and the infiltration of eosinophils in the lungs of parasitized mice but had no effect on serum IgE. In contrast, an antibody to interleukin-4 inhibited parasite-induced IgE but not the eosinophilia. These results show that interleukin-5 is important in eosinophil production in vivo and that IgE and eosinophil production are regulated by different cytokines produced by the TH2 subset of CD4-expressing T cells.
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