Hematopoiesis: how does it happen?
SH Orkin - Current opinion in cell biology, 1995 - Elsevier
Current opinion in cell biology, 1995•Elsevier
Hematopoiesis entails the generation of stem cells, the proliferation and maintenance of
multipotential progenitors, and lineage commitment and maturation. During the past year,
critical components of these steps have been defined. Notable are gene-targeting
experiments in mice in which one or more hematopoietic lineages have been shown to be
ablated upon inactivation of several nuclear regulatory proteins (GATA-2, Tal-1/SCL,
Rbtn2/LMO2, PU. 1, Ikaros, E2A, and Pax-5), and experiments that establish GATA-1 as a …
multipotential progenitors, and lineage commitment and maturation. During the past year,
critical components of these steps have been defined. Notable are gene-targeting
experiments in mice in which one or more hematopoietic lineages have been shown to be
ablated upon inactivation of several nuclear regulatory proteins (GATA-2, Tal-1/SCL,
Rbtn2/LMO2, PU. 1, Ikaros, E2A, and Pax-5), and experiments that establish GATA-1 as a …
Hematopoiesis entails the generation of stem cells, the proliferation and maintenance of multipotential progenitors, and lineage commitment and maturation. During the past year, critical components of these steps have been defined. Notable are gene-targeting experiments in mice in which one or more hematopoietic lineages have been shown to be ablated upon inactivation of several nuclear regulatory proteins (GATA-2, Tal-1/SCL, Rbtn2/LMO2, PU.1, Ikaros, E2A, and Pax-5), and experiments that establish GATA-1 as a factor capable of programming at least three lineages (erythroid, thrombocytic, and eosinophilic) from a transformed avian progenitor cell.
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