[HTML][HTML] Cloning and tyrosine phosphorylation of a novel invertebrate immunocyte protein containing immunoreceptor tyrosine-based activation motifs
H Takahashi, G Ishikawa, K Ueki, K Azumi… - Journal of Biological …, 1997 - ASBMB
Immunoreceptor tyrosine-based activation motif (ITAM) plays an important role in signal
transduction through mammalian T-cell and B-cell antigen receptors and Fc receptors. The
ITAM has been found only in vertebrate immunocytes. Ascidians are intriguing invertebrates
from the viewpoint of the evolution of immune systems because they are considered to be
ancestors of the vertebrates. We have previously shown that the monoclonal antibody A74
inhibits cellular defense reactions of the ascidian. In the present studies, we found that the …
transduction through mammalian T-cell and B-cell antigen receptors and Fc receptors. The
ITAM has been found only in vertebrate immunocytes. Ascidians are intriguing invertebrates
from the viewpoint of the evolution of immune systems because they are considered to be
ancestors of the vertebrates. We have previously shown that the monoclonal antibody A74
inhibits cellular defense reactions of the ascidian. In the present studies, we found that the …
