Role of HDL phospholipid in efflux of cell cholesterol to whole serum: studies with human apoA-I transgenic rats.
N Fournier, M de la Llera Moya, BF Burkey… - Journal of lipid …, 1996 - ASBMB
Sera of transgenic rats expressing human apoA-I were tested for their ability to stimulate
efflux of radiolabeled cholesterol from Fu5AH rat hepatoma cells. Expression of human
apoA-I resulted in a dose-dependent increase in HDL, as measured by both HDL-
cholesterol and HDL-phospholipid, and produced a decrease in rat apoA-I. In rats
expressing high concentrations of human apoA-I (TgR [hAI] high, human apoA-I> 250
mg/dl), the increase in HDL-phospholipid was not proportional to the increase in human …
efflux of radiolabeled cholesterol from Fu5AH rat hepatoma cells. Expression of human
apoA-I resulted in a dose-dependent increase in HDL, as measured by both HDL-
cholesterol and HDL-phospholipid, and produced a decrease in rat apoA-I. In rats
expressing high concentrations of human apoA-I (TgR [hAI] high, human apoA-I> 250
mg/dl), the increase in HDL-phospholipid was not proportional to the increase in human …
