MPTP: a review of its mechanisms of neurotoxicity
S Przedborski, M Vila - Clinical Neuroscience Research, 2001 - Elsevier
1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) causes damage to substantia nigra
pars compacta (SNpc) dopaminergic (DA) neurons as seen in Parkinson's disease (PD).
After systemic administration of MPTP, its active metabolite, MPP+, accumulates within SNpc
DA neurons, where it inhibits ATP production and stimulates superoxide radical formation.
The produced superoxide radicals react with nitric oxide (NO) to produce peroxynitrite, a
highly reactive tissue-damaging species that damages proteins by oxidation and nitration …
pars compacta (SNpc) dopaminergic (DA) neurons as seen in Parkinson's disease (PD).
After systemic administration of MPTP, its active metabolite, MPP+, accumulates within SNpc
DA neurons, where it inhibits ATP production and stimulates superoxide radical formation.
The produced superoxide radicals react with nitric oxide (NO) to produce peroxynitrite, a
highly reactive tissue-damaging species that damages proteins by oxidation and nitration …
