[HTML][HTML] Inhibition of vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation by a peptide corresponding to the exon 7-encoded domain of …
S Soker, S Gollamudi-Payne, H Fidder… - Journal of Biological …, 1997 - ASBMB
Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells (EC) in
vitro and a major regulator of angiogenesis in vivo. VEGF 121 and VEGF 165 are the most
abundant of the five known VEGF isoforms. The structural difference between these two is
the presence in VEGF 165 of 44 amino acids encoded by exon 7 lacking in VEGF 121. It was
previously shown that VEGF 165 and VEGF 121 both bind to KDR/Flk-1 and Flt-1 but that
VEGF 165 binds in addition to a novel receptor (Soker, S., Fidder, H., Neufeld, G., and …
vitro and a major regulator of angiogenesis in vivo. VEGF 121 and VEGF 165 are the most
abundant of the five known VEGF isoforms. The structural difference between these two is
the presence in VEGF 165 of 44 amino acids encoded by exon 7 lacking in VEGF 121. It was
previously shown that VEGF 165 and VEGF 121 both bind to KDR/Flk-1 and Flt-1 but that
VEGF 165 binds in addition to a novel receptor (Soker, S., Fidder, H., Neufeld, G., and …
