[HTML][HTML] IRS2 takes center stage in the development of type 2 diabetes
MJ Brady - The Journal of clinical investigation, 2004 - Am Soc Clin Investig
MJ Brady
The Journal of clinical investigation, 2004•Am Soc Clin InvestigThe etiology of type 2 diabetes is characterized by obesity, insulin and leptin resistance, and
compensatory β cell hyperplasia followed by islet degeneration, resulting in the eventual
dysregulation of glucose and lipid homeostasis. The recent identification of insulin receptor
substrate 2 (IRS2) as a central player in the pathophysiology of many of these processes
suggests a potentially unifying molecular link underlying the initiation and progression of
type 2 diabetes.
compensatory β cell hyperplasia followed by islet degeneration, resulting in the eventual
dysregulation of glucose and lipid homeostasis. The recent identification of insulin receptor
substrate 2 (IRS2) as a central player in the pathophysiology of many of these processes
suggests a potentially unifying molecular link underlying the initiation and progression of
type 2 diabetes.
The etiology of type 2 diabetes is characterized by obesity, insulin and leptin resistance, and compensatory β cell hyperplasia followed by islet degeneration, resulting in the eventual dysregulation of glucose and lipid homeostasis. The recent identification of insulin receptor substrate 2 (IRS2) as a central player in the pathophysiology of many of these processes suggests a potentially unifying molecular link underlying the initiation and progression of type 2 diabetes.
The Journal of Clinical Investigation