Opioid-induced proliferation through the MAPK pathway in cultures of adult hippocampal progenitors
AI Persson, T Thorlin, C Bull, PS Eriksson - Molecular and Cellular …, 2003 - Elsevier
Administration of opioid agonists or antagonists has been reported to regulate proliferation
or survival of neural progenitors in vivo. Here we report that β-endorphin and selective mu-
opioid receptor (MOR) and delta-opioid receptor (DOR) agonists stimulate proliferation of
isolated rat adult hippocampal progenitors (AHPs). The AHPs were found to express DORs
and MORs, but not kappa-opioid receptors. Incubation with β-endorphin for 48 h increased
the number of AHPs found in mitosis, the total DNA content, and the expression of …
or survival of neural progenitors in vivo. Here we report that β-endorphin and selective mu-
opioid receptor (MOR) and delta-opioid receptor (DOR) agonists stimulate proliferation of
isolated rat adult hippocampal progenitors (AHPs). The AHPs were found to express DORs
and MORs, but not kappa-opioid receptors. Incubation with β-endorphin for 48 h increased
the number of AHPs found in mitosis, the total DNA content, and the expression of …
