Tissue expression of inducible nitric oxide synthase requires IFN-γ production by infiltrating splenic T cells: more evidence for immunosuppression by nitric oxide
RC van der Veen, TA Dietlin, FM Hofman - Journal of neuroimmunology, 2003 - Elsevier
The cause of increased severity of experimental allergic encephalomyelitis (EAE) in
inducible nitric oxide synthase (iNOS)−/− or IFN-γ−/− mice remains unclear. Transient
chimeras were generated to examine the source of iNOS-inducing IFN-γ in the central
nervous system (CNS). IFNγ−/− donor cells induced severe EAE but no iNOS expression in
the CNS of wild-type recipients upon their immunization. By contrast, milder EAE, but strong
iNOS expression was induced in immunized recipients of wild-type donor spleen cells …
inducible nitric oxide synthase (iNOS)−/− or IFN-γ−/− mice remains unclear. Transient
chimeras were generated to examine the source of iNOS-inducing IFN-γ in the central
nervous system (CNS). IFNγ−/− donor cells induced severe EAE but no iNOS expression in
the CNS of wild-type recipients upon their immunization. By contrast, milder EAE, but strong
iNOS expression was induced in immunized recipients of wild-type donor spleen cells …
