Expression of G1-S modulators (p53, p16, p27, cyclin D1, Rb) and Smad4/Dpc4 in intrahepatic cholangiocarcinoma
YK Kang, WH Kim, JJ Jang - Human pathology, 2002 - Elsevier
Aberrations of G1-S cell cycle arrest and TGF-[beta]/Smad pathway are critical events in
human carcinogenesis. We studied alterations of both pathways by immunohistochemical
staining for p53, p16, p27, cyclin D1, Rb and Smad4/Dpc4 in 42 intrahepatic
cholangiocarcinomas (ICCs). Abnormal nuclear overexpression of p53 and cyclin D1 was
noted in 15 (35.7%) and 26 (61.9%) cases, respectively. Total loss of p16, p27, Rb and
Smad4 was detected in 15 (35.7%), 13 (31.0%), 5 (11.9%) and 19 (45.2%) cases …
human carcinogenesis. We studied alterations of both pathways by immunohistochemical
staining for p53, p16, p27, cyclin D1, Rb and Smad4/Dpc4 in 42 intrahepatic
cholangiocarcinomas (ICCs). Abnormal nuclear overexpression of p53 and cyclin D1 was
noted in 15 (35.7%) and 26 (61.9%) cases, respectively. Total loss of p16, p27, Rb and
Smad4 was detected in 15 (35.7%), 13 (31.0%), 5 (11.9%) and 19 (45.2%) cases …
