[HTML][HTML] Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner
E Biro, KN Sturk-Maquelin, GMT Vogel… - Journal of Thrombosis …, 2003 - Elsevier
Background: Circulating microparticles of various cell types are present in healthy
individuals and, in varying numbers and antigenic composition, in various disease states. To
what extent these microparticles contribute to coagulation in vivo is unknown. Objectives: To
examine the in vivo thrombogenicity of human microparticles. Methods: Microparticles were
isolated from pericardial blood of cardiac surgery patients and venous blood of healthy
individuals. Their numbers, cellular source, and tissue factor (TF) exposure were determined …
individuals and, in varying numbers and antigenic composition, in various disease states. To
what extent these microparticles contribute to coagulation in vivo is unknown. Objectives: To
examine the in vivo thrombogenicity of human microparticles. Methods: Microparticles were
isolated from pericardial blood of cardiac surgery patients and venous blood of healthy
individuals. Their numbers, cellular source, and tissue factor (TF) exposure were determined …
