[HTML][HTML] Interferon-γ-mediated activation and ubiquitin-proteasome-dependent degradation of PPARγ in adipocytes
ZE Floyd, JM Stephens - Journal of Biological Chemistry, 2002 - ASBMB
Interferon-γ (IFNγ) treatment of adipocytes results in a down-regulation of the peroxisome
proliferator-activated receptor γ (PPARγ). The decrease in PPARγ expression is mediated by
inhibition of PPARγ synthesis and increased degradation of PPARγ. In this study, we
demonstrate that both PPARγ1 and PPARγ2 are targeted to the proteasome under basal
conditions and that PPARγ1 is more labile than PPARγ2. The IFNγ-induced increase in
PPARγ turnover is blocked by proteasome inhibition and is accompanied by an increase in …
proliferator-activated receptor γ (PPARγ). The decrease in PPARγ expression is mediated by
inhibition of PPARγ synthesis and increased degradation of PPARγ. In this study, we
demonstrate that both PPARγ1 and PPARγ2 are targeted to the proteasome under basal
conditions and that PPARγ1 is more labile than PPARγ2. The IFNγ-induced increase in
PPARγ turnover is blocked by proteasome inhibition and is accompanied by an increase in …