[HTML][HTML] Elimination of cyclin D1 in vertebrate cells leads to an altered cell cycle phenotype, which is rescued by overexpression of murine cyclins D1, D2, or D3 but not …
JM Lahti, H Li, VJ Kidd - Journal of Biological Chemistry, 1997 - ASBMB
DT40 lymphoma B-cells normally express cyclins D1 and D2 but not D3. When cyclin D1
expression was extinguished in these cells by gene knockout, specific alterations in their
ability to transit the cell cycle were observed. These changes are exemplified by a delay of
approximately 2 h in their progression through a normal 14-h cell cycle. This delay results in
an increase in the number of cells in the G 2/M phase population, most likely due to
triggering of checkpoints in G 2/M, inability to enter G 1 normally, and/or alterations of crucial …
expression was extinguished in these cells by gene knockout, specific alterations in their
ability to transit the cell cycle were observed. These changes are exemplified by a delay of
approximately 2 h in their progression through a normal 14-h cell cycle. This delay results in
an increase in the number of cells in the G 2/M phase population, most likely due to
triggering of checkpoints in G 2/M, inability to enter G 1 normally, and/or alterations of crucial …
