Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2
YJ Liu, C Barthélémy, O De Bouteiller, C Arpin… - Immunity, 1995 - cell.com
YJ Liu, C Barthélémy, O De Bouteiller, C Arpin, D Isabelle, J Banchereau
Immunity, 1995•cell.comHuman memory B cells that carry mutated IgV region genes were isolated from tonsils by
negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma
cells. They were mainly found within the intraepithellal areas, but not in the B cell follicles of
human tonsils. Memory B cells but not naive B cells have the capacity to present antigen
directly to T cells, owing to the constitutive expression of the accessory molecules B7-l/CD80
and B7-2/CD88. Signals through antigen receptorsand CD40 antigen result in these two …
negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma
cells. They were mainly found within the intraepithellal areas, but not in the B cell follicles of
human tonsils. Memory B cells but not naive B cells have the capacity to present antigen
directly to T cells, owing to the constitutive expression of the accessory molecules B7-l/CD80
and B7-2/CD88. Signals through antigen receptorsand CD40 antigen result in these two …
Summary
Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithellal areas, but not in the B cell follicles of human tonsils. Memory B cells but not naive B cells have the capacity to present antigen directly to T cells, owing to the constitutive expression of the accessory molecules B7-l/CD80 and B7-2/CD88. Signals through antigen receptorsand CD40 antigen result in these two molecules being further upregulated more rapidly and strongly on memory B cells than on naive B cells. The unique anatomlcal localization of memory B cells beneath the surface of mucosa, together with their strong APC capacity, may explain the well-known prompt and robust secondary antibody responses.
cell.com