[HTML][HTML] Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-κB through distinct signaling pathways in fibroblast cell …
N Saito, G Courtois, A Chiba, N Yamamoto… - Journal of Biological …, 2003 - ASBMB
Latent membrane protein 1 (LMP1), an Epstein-Barr virus transforming protein, is able to
activate NF-κB through its carboxyl-terminal activation region 1 (CTAR1) and 2 (CTAR2), but
the exact role of each domain is not fully understood. Here we show that LMP1 activates NF-
κB in different NF-κB essential modulator (NEMO)-defective cell lines, but not in cells lacking
both IκB kinase 1 (IKK1) and 2 (IKK2). Mutational studies reveal that CTAR1, but not CTAR2,
mediates NEMO-independent NF-κB activation and that this process largely depends on …
activate NF-κB through its carboxyl-terminal activation region 1 (CTAR1) and 2 (CTAR2), but
the exact role of each domain is not fully understood. Here we show that LMP1 activates NF-
κB in different NF-κB essential modulator (NEMO)-defective cell lines, but not in cells lacking
both IκB kinase 1 (IKK1) and 2 (IKK2). Mutational studies reveal that CTAR1, but not CTAR2,
mediates NEMO-independent NF-κB activation and that this process largely depends on …