[HTML][HTML] Interferon-γ augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells
T Hisamatsu, M Suzuki, DK Podolsky - Journal of Biological Chemistry, 2003 - ASBMB
Although intestinal epithelial cells appear to be functionally hyporesponsive to normal
intestinal flora, human intestinal epithelial cells can respond to enteroinvasive bacteria and
induce an inflammatory response. This initial inflammatory response leads to the recruitment
of polymorphonuclear leukocytes to the affected site in vitro and in vivo. CARD4/NOD1 is a
potential cytosolic receptor for peptidoglycan in mammalian cells that resembles pathogen-
resistant proteins of plants. In this context, CARD4/NOD1 is a candidate for a recognition …
intestinal flora, human intestinal epithelial cells can respond to enteroinvasive bacteria and
induce an inflammatory response. This initial inflammatory response leads to the recruitment
of polymorphonuclear leukocytes to the affected site in vitro and in vivo. CARD4/NOD1 is a
potential cytosolic receptor for peptidoglycan in mammalian cells that resembles pathogen-
resistant proteins of plants. In this context, CARD4/NOD1 is a candidate for a recognition …