HIFs, hypoxia, and vascular development
KL Covello, MC Simon - Current topics in developmental biology, 2004 - Elsevier
Cellular oxygen (O 2) concentrations are tightly regulated to maintain ATP levels required for
metabolic reactions in the human body. Responses to changes in O 2 concentrations are
primarily regulated by the transcription factor hypoxia inducible factor (HIF). HIF activates
transcription of genes that increase systemic O 2 delivery or provide cellular metabolic
adaptation under conditions of hypoxia. HIF activity is essential for embryogenesis and
various processes in postnatal life, and therefore, HIF levels need to be precisely controlled …
metabolic reactions in the human body. Responses to changes in O 2 concentrations are
primarily regulated by the transcription factor hypoxia inducible factor (HIF). HIF activates
transcription of genes that increase systemic O 2 delivery or provide cellular metabolic
adaptation under conditions of hypoxia. HIF activity is essential for embryogenesis and
various processes in postnatal life, and therefore, HIF levels need to be precisely controlled …
