[HTML][HTML] ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1
JM Swiercz, T Worzfeld, S Offermanns - Journal of biological chemistry, 2008 - ASBMB
Sema4D-induced activation of plexin-B1 has been reported to evoke different and
sometimes opposing cellular responses. The mechanisms underlying the versatility of plexin-
B1-mediated effects are not clear. Plexin-B1 can associate with the receptor tyrosine kinases
ErbB-2 and Met. Here we show that Sema4D-induced activation and inactivation of RhoA
require ErbB-2 and Met, respectively. In breast carcinoma cells, Sema4D can have pro-and
anti-migratory effects depending on the presence of ErbB-2 and Met, and the exchange of …
sometimes opposing cellular responses. The mechanisms underlying the versatility of plexin-
B1-mediated effects are not clear. Plexin-B1 can associate with the receptor tyrosine kinases
ErbB-2 and Met. Here we show that Sema4D-induced activation and inactivation of RhoA
require ErbB-2 and Met, respectively. In breast carcinoma cells, Sema4D can have pro-and
anti-migratory effects depending on the presence of ErbB-2 and Met, and the exchange of …