Cytoplasmic domains of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor β chain (hβc) responsible for human GM-CSF-induced …
T Matsuguchi, MB Lilly, AS Kraft - Journal of Biological Chemistry, 1998 - ASBMB
Granulocyte-macrophage colony-stimulating factor (GM-CSF) regulates differentiation,
survival, and proliferation of myeloid progenitor cells. The biologic actions of GM-CSF are
mediated by its binding to the α and β subunits of the GM-CSF receptor (GM-CSFRα and βc,
respectively). To determine whether identical regions of the βc protein mediate both cell
growth and differentiation, we expressed cDNA constructs encoding the human wild-type
(897 amino acids) and truncated βc (hβc) subunits along with the wild-type human GM …
survival, and proliferation of myeloid progenitor cells. The biologic actions of GM-CSF are
mediated by its binding to the α and β subunits of the GM-CSF receptor (GM-CSFRα and βc,
respectively). To determine whether identical regions of the βc protein mediate both cell
growth and differentiation, we expressed cDNA constructs encoding the human wild-type
(897 amino acids) and truncated βc (hβc) subunits along with the wild-type human GM …
