[HTML][HTML] Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed …

AD Schimmer, EH Estey, G Borthakur… - Journal of Clinical …, 2009 - ncbi.nlm.nih.gov
AD Schimmer, EH Estey, G Borthakur, BZ Carter, GJ Schiller, MS Tallman, JK Altman…
Journal of Clinical Oncology, 2009ncbi.nlm.nih.gov
Phase I/II Trial of AEG35156 X-Linked Inhibitor of Apoptosis Protein Antisense
Oligonucleotide Combined With Idarubicin and Cytarabine in Patients With Relapsed or
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Abstract
Purpose
X-linked inhibitor of apoptosis protein (XIAP) is an inhibitor of caspases 3 and 9 which are overexpressed in acute myeloid leukemia (AML) and may contribute to chemoresistance. We report on a phase I/II trial of the XIAP antisense oligonucleotide
ncbi.nlm.nih.gov