[HTML][HTML] Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription
KB Kegel, AR Meloni, Y Yi, YJ Kim, E Doyle… - Journal of Biological …, 2002 - ASBMB
Huntingtin is a protein of unknown function that contains a polyglutamine tract, which is
expanded in patients with Huntington's disease (HD). We investigated the localization and a
potential function for huntingtin in the nucleus. In human fibroblasts from normal and HD
patients, huntingtin localized diffusely in the nucleus and in subnuclear compartments
identified as speckles, promyelocytic leukemia protein bodies, and nucleoli. Huntingtin-
positive nuclear bodies redistributed after treatment with sodium butyrate. By Western blot …
expanded in patients with Huntington's disease (HD). We investigated the localization and a
potential function for huntingtin in the nucleus. In human fibroblasts from normal and HD
patients, huntingtin localized diffusely in the nucleus and in subnuclear compartments
identified as speckles, promyelocytic leukemia protein bodies, and nucleoli. Huntingtin-
positive nuclear bodies redistributed after treatment with sodium butyrate. By Western blot …