[HTML][HTML] A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for Huntington disease* S
C Zabel, L Mao, B Woodman, M Rohe… - Molecular & Cellular …, 2009 - ASBMB
Huntington disease (HD) is fatal in humans within 15–20 years of symptomatic disease.
Although late stage HD has been studied extensively, protein expression changes that occur
at the early stages of disease and during disease progression have not been reported. In
this study, we used a large two-dimensional gel/mass spectrometry-based proteomics
approach to investigate HD-induced protein expression alterations and their kinetics at very
early stages and during the course of disease. The murine HD model R6/2 was investigated …
Although late stage HD has been studied extensively, protein expression changes that occur
at the early stages of disease and during disease progression have not been reported. In
this study, we used a large two-dimensional gel/mass spectrometry-based proteomics
approach to investigate HD-induced protein expression alterations and their kinetics at very
early stages and during the course of disease. The murine HD model R6/2 was investigated …