Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2′ dG
SM Hersch, S Gevorkian, K Marder, C Moskowitz… - Neurology, 2006 - AAN Enterprises
SM Hersch, S Gevorkian, K Marder, C Moskowitz, A Feigin, M Cox, P Como, C Zimmerman…
Neurology, 2006•AAN EnterprisesIn a randomized, double-blind, placebo-controlled study in 64 subjects with Huntington
disease (HD), 8 g/day of creatine administered for 16 weeks was well tolerated and safe.
Serum and brain creatine concentrations increased in the creatine-treated group and
returned to baseline after washout. Serum 8-hydroxy-2′-deoxyguanosine (8OH2′ dG)
levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by
creatine treatment.
disease (HD), 8 g/day of creatine administered for 16 weeks was well tolerated and safe.
Serum and brain creatine concentrations increased in the creatine-treated group and
returned to baseline after washout. Serum 8-hydroxy-2′-deoxyguanosine (8OH2′ dG)
levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by
creatine treatment.
In a randomized, double-blind, placebo-controlled study in 64 subjects with Huntington disease (HD), 8 g/day of creatine administered for 16 weeks was well tolerated and safe. Serum and brain creatine concentrations increased in the creatine-treated group and returned to baseline after washout. Serum 8-hydroxy-2′-deoxyguanosine (8OH2′dG) levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by creatine treatment.
American Academy of Neurology