Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis
JP Piret, E Minet, JP Cosse, N Ninane… - Journal of biological …, 2005 - ASBMB
Increased levels of Mcl-1 (myeloid cell factor-1) have been reported in several cancers,
suggesting an important role played by Mcl-1 in cancer cell survival. Mcl-1 is an anti-
apoptotic protein shown to delay or block apoptosis. In this work, using semiquantitative
immunofluorescence, real-time PCR, and RNase protection assay, an increase in Mcl-1
expression was detected in hepatoma HepG2 cells incubated under hypoxia or in the
presence of cobalt chloride. Through analysis of the Mcl-1 promoter sequence, a putative …
suggesting an important role played by Mcl-1 in cancer cell survival. Mcl-1 is an anti-
apoptotic protein shown to delay or block apoptosis. In this work, using semiquantitative
immunofluorescence, real-time PCR, and RNase protection assay, an increase in Mcl-1
expression was detected in hepatoma HepG2 cells incubated under hypoxia or in the
presence of cobalt chloride. Through analysis of the Mcl-1 promoter sequence, a putative …
