Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit

AC Kalil, DF Florescu - Critical care medicine, 2009 - journals.lww.com
Objective: To define the frequency and mortality rate associated with cytomegalovirus
infection in nonimmunosuppressed patients in the intensive care unit. Methods: A systematic
review up to October 2008 was performed. Pooled results were analyzed by fixed-and
random-effects models. Cochran Q and I 2 were performed for heterogeneity. Results:
Thirteen studies (n= 1258) were selected. The overall rate of active cytomegalovirus
infection was 17%(95% confidence interval [CI], 11% to 24%; p<. 0001; I 2= 86%). When the …