Quality and quantity control at the endoplasmic reticulum
RS Hegde, HL Ploegh - Current opinion in cell biology, 2010 - Elsevier
RS Hegde, HL Ploegh
Current opinion in cell biology, 2010•ElsevierThe endoplasmic reticulum (ER) is the site of maturation for secretory and membrane
proteins that together make up about one third of the cellular proteome. Cells carefully
control the synthetic output of this organelle to regulate both quality and quantity of proteins
that emerge. Here, we synthesize current concepts underlying the pathways that mediate
protein degradation from the ER and their deployment under physiologic and pathologic
conditions.
proteins that together make up about one third of the cellular proteome. Cells carefully
control the synthetic output of this organelle to regulate both quality and quantity of proteins
that emerge. Here, we synthesize current concepts underlying the pathways that mediate
protein degradation from the ER and their deployment under physiologic and pathologic
conditions.
The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins that together make up about one third of the cellular proteome. Cells carefully control the synthetic output of this organelle to regulate both quality and quantity of proteins that emerge. Here, we synthesize current concepts underlying the pathways that mediate protein degradation from the ER and their deployment under physiologic and pathologic conditions.
Elsevier