Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis
M Flamment, HL Kammoun, I Hainault… - Current opinion in …, 2010 - journals.lww.com
M Flamment, HL Kammoun, I Hainault, P Ferré, F Foufelle
Current opinion in lipidology, 2010•journals.lww.comManipulating endoplasmic reticulum stress pathway yields encouraging results for the
treatment of hepatic steatosis in rodents. However, activation of unfolded protein response is
a physiological mechanism, which is particularly important for secretory cells such as
hepatocytes and the long-term consequences of such treatments should be cautiously
evaluated.
treatment of hepatic steatosis in rodents. However, activation of unfolded protein response is
a physiological mechanism, which is particularly important for secretory cells such as
hepatocytes and the long-term consequences of such treatments should be cautiously
evaluated.
Summary
Manipulating endoplasmic reticulum stress pathway yields encouraging results for the treatment of hepatic steatosis in rodents. However, activation of unfolded protein response is a physiological mechanism, which is particularly important for secretory cells such as hepatocytes and the long-term consequences of such treatments should be cautiously evaluated.
Lippincott Williams & Wilkins