Heimburger, 4 as modified by Johns and Olson.’However, this procedure is rather complicated and causes a comparatively high mortality; besides, it was often unsuccessful in producing infarction, even in the hands of its discoverers, so it was never used for solving any physiologic or pharmacologic problem. Indeed-as far as we can establish-since its initial description in 19464 and its modification in 1954 (published as the first of a proposed series’) the method was used only for two small experiments limited to the verification of its feasibility and the descrip-tion of the morphologic changes that occur after infarction in the rat heart. 5, 6 As regards the consequences of isolated coro-nary vein ligature in the rat, we were able to find only one statement in the literature, namely: