Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice
S Haga, W Ogawa, H Inoue, K Terui, T Ogino… - Journal of …, 2005 - Elsevier
BACKGROUND/AIMS: Liver regeneration following hepatectomy is complicated and
involves a variety of interacting factors. The present study was designed to study the roles of
proliferation and hypertrophy of hepatocytes in liver regeneration following hepatectomy in
liver-specific STAT3-knockout (LS3-KO) mice lacking mitogenic activity. METHODS: Partial
hepatectomy was performed in LS3-KO and control mice. Liver regeneration was estimated
by the liver weight, cell proliferation and cell size, and the related cellular signals were …
involves a variety of interacting factors. The present study was designed to study the roles of
proliferation and hypertrophy of hepatocytes in liver regeneration following hepatectomy in
liver-specific STAT3-knockout (LS3-KO) mice lacking mitogenic activity. METHODS: Partial
hepatectomy was performed in LS3-KO and control mice. Liver regeneration was estimated
by the liver weight, cell proliferation and cell size, and the related cellular signals were …
