[HTML][HTML] The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3
C Terrenoire, MD Houslay, GS Baillie… - Journal of biological …, 2009 - ASBMB
The cardiac I Ks potassium channel is a macromolecular complex consisting of α-(KCNQ1)
and β-subunits (KCNE1) and the A kinase-anchoring protein (AKAP) Yotiao (AKAP-9), which
recruits protein kinase A) and protein phosphatase 1 to the channel. Here, we have tested
the hypothesis that specific cAMP phosphodiesterase (PDE) isoforms of the PDE4D family
that are expressed in the heart are also part of the I Ks signaling complex and contribute to
its regulation by cAMP. PDE4D isoforms co-immunoprecipitated with I Ks channels in hearts …
and β-subunits (KCNE1) and the A kinase-anchoring protein (AKAP) Yotiao (AKAP-9), which
recruits protein kinase A) and protein phosphatase 1 to the channel. Here, we have tested
the hypothesis that specific cAMP phosphodiesterase (PDE) isoforms of the PDE4D family
that are expressed in the heart are also part of the I Ks signaling complex and contribute to
its regulation by cAMP. PDE4D isoforms co-immunoprecipitated with I Ks channels in hearts …
