[HTML][HTML] The roles of different pathways in the release of cholesterol from macrophages
MP Adorni, F Zimetti, JT Billheimer, N Wang… - Journal of lipid …, 2007 - ASBMB
Cholesterol efflux occurs by different pathways, including transport mediated by specific
proteins. We determined the effect of enriching cells with free cholesterol (FC) on the release
of FC to human serum. Loading Fu5AH cells with FC had no effect on fractional efflux,
whereas enriching mouse peritoneal macrophages (MPMs) resulted in a doubling of
fractional efflux. Efflux from cholesterol-normal MPM and Fu5AH cells to 15 human sera
correlated well with HDL parameters. However, these relationships were reduced or lost …
proteins. We determined the effect of enriching cells with free cholesterol (FC) on the release
of FC to human serum. Loading Fu5AH cells with FC had no effect on fractional efflux,
whereas enriching mouse peritoneal macrophages (MPMs) resulted in a doubling of
fractional efflux. Efflux from cholesterol-normal MPM and Fu5AH cells to 15 human sera
correlated well with HDL parameters. However, these relationships were reduced or lost …