Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection
RhoA a small G-protein that has an established role in cell growth and in regulation of the
actin cytoskeleton. Far less is known about whether RhoA can modulate cell fate. We
previously reported that sustained RhoA activation induces cardiomyocyte apoptosis (Del
Re, DP, Miyamoto, S., and Brown, JH (2007) J. Biol. Chem. 282, 8069–8078). Here we
demonstrate that less chronic RhoA activation affords a survival advantage, protecting
cardiomyocytes from apoptotic insult induced by either hydrogen peroxide treatment or …
actin cytoskeleton. Far less is known about whether RhoA can modulate cell fate. We
previously reported that sustained RhoA activation induces cardiomyocyte apoptosis (Del
Re, DP, Miyamoto, S., and Brown, JH (2007) J. Biol. Chem. 282, 8069–8078). Here we
demonstrate that less chronic RhoA activation affords a survival advantage, protecting
cardiomyocytes from apoptotic insult induced by either hydrogen peroxide treatment or …
