[HTML][HTML] Physical and functional interactions of Gαq with Rho and its exchange factors
SA Sagi, TM Seasholtz, M Kobiashvili… - Journal of Biological …, 2001 - ASBMB
Recent reports have shown that several heterotrimeric protein-coupled receptors that signal
through Gα q can induce Rho-dependent responses, but the pathways that mediate the
interaction between Gα q and Rho have not yet been identified. In this report we present
evidence that Gα q expressed in COS-7 cells coprecipitates with the Rho guanine
nucleotide exchange factor (GEF) Lbc. Furthermore, Gα q expression enhances Rho-
dependent responses. Coexpressed Gα q and Lbc have a synergistic effect on the Rho …
through Gα q can induce Rho-dependent responses, but the pathways that mediate the
interaction between Gα q and Rho have not yet been identified. In this report we present
evidence that Gα q expressed in COS-7 cells coprecipitates with the Rho guanine
nucleotide exchange factor (GEF) Lbc. Furthermore, Gα q expression enhances Rho-
dependent responses. Coexpressed Gα q and Lbc have a synergistic effect on the Rho …
