[HTML][HTML] Hybrid proteasomes: induction by interferon-γ and contribution to ATP-dependent proteolysis
N Tanahashi, Y Murakami, Y Minami… - Journal of Biological …, 2000 - ASBMB
Eukaryotic cells contain various types of proteasomes. Core 20 S proteasomes (abbreviated
20 S below) have two binding sites for the regulatory particles, PA700 and PA28. PA700–20
S-PA700 complexes are known as 26 S proteasomes and are ATP-dependent machines
that degrade cell proteins. PA28 is found both in previously described complexes of the type
PA28–20 S-PA28 and in complexes that also contain PA700, as PA700–20 S-PA28. We
refer to the latter as" hybrid proteasomes." The relative amounts of the various types of …
20 S below) have two binding sites for the regulatory particles, PA700 and PA28. PA700–20
S-PA700 complexes are known as 26 S proteasomes and are ATP-dependent machines
that degrade cell proteins. PA28 is found both in previously described complexes of the type
PA28–20 S-PA28 and in complexes that also contain PA700, as PA700–20 S-PA28. We
refer to the latter as" hybrid proteasomes." The relative amounts of the various types of …
