[HTML][HTML] Oxidized low density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells via Toll-like receptors 2 and 4
X Su, L Ao, Y Shi, TR Johnson, DA Fullerton… - Journal of Biological …, 2011 - ASBMB
Vascular calcification is a common complication in atherosclerosis. Bone morphogenetic
protein-2 (BMP-2) plays an important role in atherosclerotic vascular calcification. The aim of
this study was to determine the effect of oxidized low density lipoprotein (oxLDL) on BMP-2
protein expression in human coronary artery endothelial cells (CAECs), the roles of Toll-like
receptor (TLR) 2 and TLR4 in oxLDL-induced BMP-2 expression, and the signaling
pathways involved. Human CAECs were stimulated with oxLDL. The roles of TLR2 and …
protein-2 (BMP-2) plays an important role in atherosclerotic vascular calcification. The aim of
this study was to determine the effect of oxidized low density lipoprotein (oxLDL) on BMP-2
protein expression in human coronary artery endothelial cells (CAECs), the roles of Toll-like
receptor (TLR) 2 and TLR4 in oxLDL-induced BMP-2 expression, and the signaling
pathways involved. Human CAECs were stimulated with oxLDL. The roles of TLR2 and …
