Acute effects of PYY3–36 on food intake and hypothalamic neuropeptide expression in the mouse
BG Challis, SB Pinnock, AP Coll, RN Carter… - Biochemical and …, 2003 - Elsevier
Biochemical and biophysical research communications, 2003•Elsevier
It has recently been suggested that gut-derived PYY3–36 may be involved in the central
mediation of post-prandial satiety signals. We have examined the acute effects of
peripherally administered PYY3–36 on food intake and hypothalamic gene expression of
neuropeptides in mice. A single intraperitoneal injection of PYY3–36 to mice that had been
fasted for 24h resulted in a highly significant reduction in food intake at 6 and 24h post-
injection but not at 48h. However, in freely fed mice, food intake was unaltered by PYY3–36 …
mediation of post-prandial satiety signals. We have examined the acute effects of
peripherally administered PYY3–36 on food intake and hypothalamic gene expression of
neuropeptides in mice. A single intraperitoneal injection of PYY3–36 to mice that had been
fasted for 24h resulted in a highly significant reduction in food intake at 6 and 24h post-
injection but not at 48h. However, in freely fed mice, food intake was unaltered by PYY3–36 …
It has recently been suggested that gut-derived PYY3–36 may be involved in the central mediation of post-prandial satiety signals. We have examined the acute effects of peripherally administered PYY3–36 on food intake and hypothalamic gene expression of neuropeptides in mice. A single intraperitoneal injection of PYY3–36 to mice that had been fasted for 24h resulted in a highly significant reduction in food intake at 6 and 24h post-injection but not at 48h. However, in freely fed mice, food intake was unaltered by PYY3–36 administration. In the arcuate nucleus POMC mRNA expression was significantly elevated at 6h and remained elevated at 24h following PYY3–36 injection. By contrast NPY mRNA expression in the arcuate nucleus was suppressed at 6h but not at 24h post-injection. In the lateral hypothalamus there were no differences in MCH mRNA expression at either time point. In conclusion, peripherally administered PYY3–36 has a suppressive effect on food intake that is more prominent in recently fasted mice and lasts up to 24h. This is associated with a short-lived suppression of NPY mRNA, a longer lasting increase in POMC mRNA but no change in MCH mRNA expression.
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