IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy
J Novak, BA Julian, M Tomana, J Mestecky - Seminars in nephrology, 2008 - Elsevier
Circulating immune complexes containing aberrantly glycosylated immunoglobulin A (IgA) 1
play a pivotal role in the pathogenesis of IgA nephropathy (IgAN). A portion of IgA1 secreted
by IgA1-producing cells in patients with IgAN is galactose deficient and consequently
recognized by anti glycan IgG or IgA1 antibodies. Some of the resultant immune complexes
in the circulation escape normal clearance mechanisms, deposit in the renal mesangium,
and induce glomerular injury. Recent studies of the origin of these aberrant molecules, their …
play a pivotal role in the pathogenesis of IgA nephropathy (IgAN). A portion of IgA1 secreted
by IgA1-producing cells in patients with IgAN is galactose deficient and consequently
recognized by anti glycan IgG or IgA1 antibodies. Some of the resultant immune complexes
in the circulation escape normal clearance mechanisms, deposit in the renal mesangium,
and induce glomerular injury. Recent studies of the origin of these aberrant molecules, their …
