Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells
BACKGROUND: Transmembrane activator, calcium modulator, and cyclophilin ligand
interactor (TACI) expression on B cells is upregulated by Toll-like receptor (TLR) 4.
OBJECTIVE: We sought to examine whether TACI synergizes with TLR4 in driving
immunoglobulin production by B cells and to examine the mechanism of this synergy.
METHODS: Purified mouse naive B cells were stimulated with the TACI ligand a proliferation-
inducing ligand (APRIL) and with suboptimal concentrations of the TLR4 ligand LPS in the …
interactor (TACI) expression on B cells is upregulated by Toll-like receptor (TLR) 4.
OBJECTIVE: We sought to examine whether TACI synergizes with TLR4 in driving
immunoglobulin production by B cells and to examine the mechanism of this synergy.
METHODS: Purified mouse naive B cells were stimulated with the TACI ligand a proliferation-
inducing ligand (APRIL) and with suboptimal concentrations of the TLR4 ligand LPS in the …
