[HTML][HTML] A Drosophila Model for Amyotrophic Lateral Sclerosis Reveals Motor Neuron Damage by Human SOD1*♦
MR Watson, RD Lagow, K Xu, B Zhang… - Journal of Biological …, 2008 - ASBMB
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease that leads to loss of motor
function and early death. About 5% of cases are inherited, with the majority of identified
linkages in the gene encoding copper, zinc-superoxide dismutase (SOD1). Strong evidence
indicates that the SOD1 mutations confer dominant toxicity on the protein. To provide new
insight into mechanisms of ALS, we have generated and characterized a model for familial
ALS in Drosophila with transgenic expression of human SOD1. Expression of wild type or …
function and early death. About 5% of cases are inherited, with the majority of identified
linkages in the gene encoding copper, zinc-superoxide dismutase (SOD1). Strong evidence
indicates that the SOD1 mutations confer dominant toxicity on the protein. To provide new
insight into mechanisms of ALS, we have generated and characterized a model for familial
ALS in Drosophila with transgenic expression of human SOD1. Expression of wild type or …
