Nucleosomal core histones mediate dynamic regulation of poly (ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity
Poly (ADP-ribose) polymerase 1 protein (PARP1) mediates chromatin loosening and
activates the transcription of inducible genes, but the mechanism of PARP1 regulation in
chromatin is poorly understood. We have found that PARP1 interaction with chromatin is
dynamic and that PARP1 is exchanged continuously between chromatin and nucleoplasm,
as well as between chromatin domains. Specifically, the PARP1 protein preferentially
interacts with nucleosomal particles, and although the nucleosomal linker DNA is not …
activates the transcription of inducible genes, but the mechanism of PARP1 regulation in
chromatin is poorly understood. We have found that PARP1 interaction with chromatin is
dynamic and that PARP1 is exchanged continuously between chromatin and nucleoplasm,
as well as between chromatin domains. Specifically, the PARP1 protein preferentially
interacts with nucleosomal particles, and although the nucleosomal linker DNA is not …
