Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic β-cells
M Nenquin, A Szollosi, L Aguilar-Bryan, J Bryan… - Journal of Biological …, 2004 - ASBMB
In normal β-cells glucose induces insulin secretion by activating both a triggering pathway
(closure of K ATP channels, depolarization, and rise in cytosolic [Ca 2+] i) and an amplifying
pathway (augmentation of Ca 2+ efficacy on exocytosis). It is unclear if and how nutrients
can regulate insulin secretion by β-cells lacking K ATP channels (Sur1 knockout mice). We
compared glucose-and amino acid-induced insulin secretion and [Ca 2+] i changes in
control and Sur1KO islets. In 1 mm glucose (non-stimulatory for controls), the triggering …
(closure of K ATP channels, depolarization, and rise in cytosolic [Ca 2+] i) and an amplifying
pathway (augmentation of Ca 2+ efficacy on exocytosis). It is unclear if and how nutrients
can regulate insulin secretion by β-cells lacking K ATP channels (Sur1 knockout mice). We
compared glucose-and amino acid-induced insulin secretion and [Ca 2+] i changes in
control and Sur1KO islets. In 1 mm glucose (non-stimulatory for controls), the triggering …
