[HTML][HTML] A cancer derived mutation in the retinoblastoma gene with a distinct defect for LXCXE dependent interactions
SA Henley, SM Francis, J Demone, P Ainsworth… - Cancer cell …, 2010 - Springer
Background The interaction between viral oncoproteins such as Simian virus 40 TAg,
adenovirus E1A, and human papilloma virus E7, and the retinoblastoma protein (pRB)
occurs through a well characterized peptide sequence, LXCXE, on the viral protein and a
well conserved groove in the pocket domain of pRB. Cellular proteins, such as histone
deacetylases, also use this mechanism to interact with the retinoblastoma protein to repress
transcription at cell cycle regulated genes. For these reasons this region of the pRB pocket …
adenovirus E1A, and human papilloma virus E7, and the retinoblastoma protein (pRB)
occurs through a well characterized peptide sequence, LXCXE, on the viral protein and a
well conserved groove in the pocket domain of pRB. Cellular proteins, such as histone
deacetylases, also use this mechanism to interact with the retinoblastoma protein to repress
transcription at cell cycle regulated genes. For these reasons this region of the pRB pocket …
[PDF][PDF] Primary research A cancer derived mutation in the Retinoblastoma gene with a distinct defect for LXCXE dependent interactions
SA Henley, SM Francis, J Demone, P Ainsworth… - 2010 - cancerci.biomedcentral.com
Background: The interaction between viral oncoproteins such as Simian virus 40 TAg,
adenovirus E1A, and human papilloma virus E7, and the retinoblastoma protein (pRB)
occurs through a well characterized peptide sequence, LXCXE, on the viral protein and a
well conserved groove in the pocket domain of pRB. Cellular proteins, such as histone
deacetylases, also use this mechanism to interact with the retinoblastoma protein to repress
transcription at cell cycle regulated genes. For these reasons this region of the pRB pocket …
adenovirus E1A, and human papilloma virus E7, and the retinoblastoma protein (pRB)
occurs through a well characterized peptide sequence, LXCXE, on the viral protein and a
well conserved groove in the pocket domain of pRB. Cellular proteins, such as histone
deacetylases, also use this mechanism to interact with the retinoblastoma protein to repress
transcription at cell cycle regulated genes. For these reasons this region of the pRB pocket …
