Prostaglandin (PG) D2 is the major cyclooxygenase metabolite of arachidonic acid
produced by mast cells in response to allergen in diseases, such as asthma, atopic
dermatitis, allergic rhinitis and allergic conjunctivitis. However, whether PGD2 regulates
allergic process per se, and, if so, whether it facilitates or down-regulates the disease
process has remained unknown. PGD2 exerts its actions by binding to two types of specific
cell surface receptor. One is DP (the PGD receptor) and the other is chemoattractant …