[HTML][HTML] TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells
S Bollimuntha, BB Singh, S Shavali, SK Sharma… - Journal of Biological …, 2005 - ASBMB
Mammalian homologues of the Drosophila canonical transient receptor potential (TRP)
proteins have been implicated to function as plasma membrane Ca 2+ channels. This study
examined the role of TRPC1 in human neuroblastoma (SH-SY5Y) cells. SH-SY5Y cells
treated with an exogenous neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP+) significantly
decreased TRPC1 protein levels. Confocal microscopy on SH-SY5Y cells treatment with
MPP+ showed decreased plasma membrane staining of TRPC1. Importantly …
proteins have been implicated to function as plasma membrane Ca 2+ channels. This study
examined the role of TRPC1 in human neuroblastoma (SH-SY5Y) cells. SH-SY5Y cells
treated with an exogenous neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP+) significantly
decreased TRPC1 protein levels. Confocal microscopy on SH-SY5Y cells treatment with
MPP+ showed decreased plasma membrane staining of TRPC1. Importantly …