[HTML][HTML] The homocysteine-inducible endoplasmic reticulum stress protein counteracts calcium store depletion and induction of CCAAT enhancer-binding protein …
S Chigurupati, Z Wei, C Belal, M Vandermey… - Journal of biological …, 2009 - ASBMB
The endoplasmic reticulum (ER) is a key organelle regulating intracellular Ca 2+
homeostasis. Oxidants and mitochondria-derived free radicals can target ER-based Ca 2+
regulatory proteins and cause uncontrolled Ca 2+ release that may contribute to protracted
ER stress and apoptosis. Several ER stress proteins have been suggested to counteract the
deregulation of ER Ca 2+ homeostasis and ER stress. Here we showed that knockdown of
Herp, an ubiquitin-like domain containing ER stress protein, renders PC12 and MN9D cells …
homeostasis. Oxidants and mitochondria-derived free radicals can target ER-based Ca 2+
regulatory proteins and cause uncontrolled Ca 2+ release that may contribute to protracted
ER stress and apoptosis. Several ER stress proteins have been suggested to counteract the
deregulation of ER Ca 2+ homeostasis and ER stress. Here we showed that knockdown of
Herp, an ubiquitin-like domain containing ER stress protein, renders PC12 and MN9D cells …