Differential Roles of the Insulin and Insulin-like Growth Factor-I (IGF-I) Receptors in Response to Insulin and IGF-I*[boxs]
A Entingh-Pearsall, CR Kahn - Journal of Biological Chemistry, 2004 - ASBMB
Insulin and insulin-like growth factor-I (IGF-I) receptors are highly homologous tyrosine
kinase receptors that share many common steps in their signaling pathways and have
ligands that can bind to either receptor with differing affinities. To define precisely the
signaling specific to the insulin receptor (IR) or the IGF-I receptor, we have generated brown
preadipocyte cell lines that lack either receptor (insulin receptor knockout (IRKO) or insulin-
like growth factor receptor knockout (IGFRKO)). Control preadipocytes expressed fewer …
kinase receptors that share many common steps in their signaling pathways and have
ligands that can bind to either receptor with differing affinities. To define precisely the
signaling specific to the insulin receptor (IR) or the IGF-I receptor, we have generated brown
preadipocyte cell lines that lack either receptor (insulin receptor knockout (IRKO) or insulin-
like growth factor receptor knockout (IGFRKO)). Control preadipocytes expressed fewer …
