[HTML][HTML] Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases
MD Jackson, MT Schmidt, NJ Oppenheimer… - Journal of Biological …, 2003 - ASBMB
Silent information regulator 2 (Sir2) enzymes catalyze NAD+-dependent protein/histone
deacetylation, where the acetyl group from the lysine ϵ-amino group is transferred to the
ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-
ribose. Sir2 proteins have been shown to regulate gene silencing, metabolic enzymes, and
life span. Recently, nicotinamide has been implicated as a direct negative regulator of
cellular Sir2 function; however, the mechanism of nicotinamide inhibition was not …
deacetylation, where the acetyl group from the lysine ϵ-amino group is transferred to the
ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-
ribose. Sir2 proteins have been shown to regulate gene silencing, metabolic enzymes, and
life span. Recently, nicotinamide has been implicated as a direct negative regulator of
cellular Sir2 function; however, the mechanism of nicotinamide inhibition was not …