Hypoxemia is associated with mitochondrial DNA damage and gene induction: implications for cardiac disease
M Corral-Debrinski, G Stepien, JM Shoffner, MT Lott… - Jama, 1991 - jamanetwork.com
Objective.—Oxidative phosphorylation (OXPHOS) deficiency due to hypoxemia or other
causes was hypothesized to increase oxygen radical generation, damage mitochondrial
DNA (mtDNA), and reduce adenosine triphosphate synthesis, resulting in compensatory
OXPHOS gene induction. Therefore, we investigated the levels of mtDNA damage and
OXPHOS transcripts in normal and ischemic hearts, and then in other forms of heart disease.
Design.—DNA was extracted from the heart and the levels of the common 4977 base pair …
causes was hypothesized to increase oxygen radical generation, damage mitochondrial
DNA (mtDNA), and reduce adenosine triphosphate synthesis, resulting in compensatory
OXPHOS gene induction. Therefore, we investigated the levels of mtDNA damage and
OXPHOS transcripts in normal and ischemic hearts, and then in other forms of heart disease.
Design.—DNA was extracted from the heart and the levels of the common 4977 base pair …
