The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [1H]-MRS
The NMDA receptor antagonist ketamine can induce a rapid improvement in depressive
symptoms that often endures for days after a single intravenous dose. The
pharmacodynamic basis for this effect is poorly understood. Using a proton magnetic
resonance spectroscopy ([1H]-MRS) method that previously detected a normalization of
amino acid neurotransmitter (AANt) content after chronic treatment with conventional
antidepressant treatments, we examined whether the acute action of ketamine is associated …
symptoms that often endures for days after a single intravenous dose. The
pharmacodynamic basis for this effect is poorly understood. Using a proton magnetic
resonance spectroscopy ([1H]-MRS) method that previously detected a normalization of
amino acid neurotransmitter (AANt) content after chronic treatment with conventional
antidepressant treatments, we examined whether the acute action of ketamine is associated …
